ACTIVE IMMUNIZATION AGAINST DIPHTHERIA IN A LARGE CHILD-CARING INSTITUTION

Diphtheria in an Institution

For several years we have had frequent small outbreaks of diphtheria. In *924, there were fifteen apparently separate outbreaks with a total of twenty eases, and in the early part of 1925, there were at different times six patients <ind eleven members of the staff down with mild attacks of the same thing. Of the whole thirty-seven cases, only two were serious, but it was obvious that at any tim...

Active Immunization against Poliomyelitis

1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.

Diphtheria Immunization *

AT the beginning of the twentieth century diphtheria occupied a unique position in contrast to other infectious diseases. Its symptoms and course were well known and accurately described, the causal organism definitely recognized, and a specific remedy was available for its treatment, yet in spite of this wealth of scientific knowledge the control and prevention of the disease had proved a comp...

Active Immunization against Poliomyelitis in Monkeys

1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, ...

Oral Immunization against Diphtheria and Tetanus Infections by Fluid Dphtheria and Tetanus Toxoids